Cytotoxic T lymphocytes play a crucial role in adaptive immunity, primarily defending against tumors and viruses. These cells develop within the thymus gland and undergo rapid activation upon ...

Scientists mapped the gene regulatory networks responsible for progressive differentiation states of tumor-infiltrating T cells, using a technology known as single-cell CRISPR screening to knock out ...

Vijay K. Kuchroo, PhD, DVM, of the Gene Lay Institute of Immunology and Inflammationof Brigham and Women’s Hospital, Massachusetts General Hospital and Harvard Medical School and the Ann Romney Center ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...