The low-to-moderate resolution of linkage analysis in complex traits has underscored the need to identify disease phenotypes with presumed genetic homogeneity. Bipolar disorder (BP) accompanied by ...

许多年来，连锁分析（linkage analysis）都是对孟德尔疾病和具有家族聚集倾向的复杂性状进行遗传作图（genetic mapping）的主要工具。而近几年来，随着研究焦点向常见变异（common variants）的转移，全基因组关联研究（genome-wide association studies，GWAS）被广泛采用，很 ...

Although there is considerable evidence for a strong genetic component to idiopathic autism, several genome-wide screens for susceptibility genes have been carried out with limited concordance of ...

In this paper we propose a new class of statistics to test a simple hypothesis against a family of alternatives characterized by a mixture model. Unlike the likelihood ratio statistic, whose large ...

Microarray analysis revealed 1528 genes expressed differentially between the two parent strains. They then used an oligonucleotide array technique to generate a genetic map with 3312 markers. The ...