EXPORT MECHANISM: The tRNA must mature inside the nucleus before export. tRNAs are aminoacylated, and only tRNAs charged with an amino acid are exported efficiently. Export occurs when the tRNA is ...

Scientists have uncovered key new information towards understanding the crucial first step in protein synthesis, the process by which the genetic code, harbored within DNA and copied into RNA, is ...

Ribosome Assembly: New research shows that neurons not only synthesize proteins locally near synapses. They can also assemble ribosomes at synapses. Dynamic Regulation: Local ribosome maturation ...

Rush hour never ceases at the nucleus’ border. Gene products begin their lives in the nucleus as strands of mRNA that ship out into the cytoplasm, where they serve as templates for protein synthesis.

This narrated animation illustrates the process of protein synthesis, starting with chromosomal DNA inside the cell's nucleus. A gene is transcribed into messenger RNA, which leaves the nucleus and ...

An international team of scientists have used advanced microscopy to image how ribosomes recruit to mRNA. Within a cell, DNA carries the genetic code for building proteins. To build proteins, the cell ...

We have investigated the contribution of an individual nucleus to intracellular and surface membranes in multinucleated muscle fibers. Using a retroviral vector, we introduced the gene encoding the ...

A so-called pathological protein long associated with Parkinson's disease has been found in a new study to trigger cells to increase protein synthesis, an event that eventually kills the subset of ...

Factor-pooling by ribosomes caught on video using state-of-art high-speed atomic force microscopy technology. Ribosomes are the complexes of ribonucleoproteins at the heart of protein synthesis in ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, No. 8 (Apr. 15, 1987), pp. 2317-2321 (5 pages) The subcellular distribution of v-sis-related protein(s) was ...