实验结果完全符合预期。在野生型HEK293T细胞中，“附加编辑”几乎无法诱导任何碱基突变。然而，一旦敲除了TARG1基因，情况发生逆转：在目标胸腺嘧啶位点，碱基突变频率显著提升。例如，在EMX1基因靶点，突变频率从几乎为零跃升至约9%。这一结果证实T ...

Researchers at the University of Bath have discovered how DNA damage caused by a faulty DNA protection and repair system can ...

Researchers have uncovered a previously unknown mechanism that safeguards the chromosome ends from being mistakenly repaired ...

Reporting in Nature, scientists have identified a novel process that protects the ends of chromosomes from incorrectly applied DNA repair.. | Cell And Molecular Biology ...

New research from the Kind Group at the Hubrecht Institute sheds light on how cells repair damaged DNA. For the first time, the team has mapped the activity of repair proteins in individual human ...

Researchers have unveiled a new type of nanostructure that dramatically improves CRISPR delivery. Called lipid nanoparticle ...

A new study in Nature Plants reveals that DNA double-strand break repair (DSBR) pathways help prevent gene transfer from organelles to the nucleus in plants. Disruption of DSBR increases the risk ...

The Pol-theta enzyme (blue) joins two parts of a broken DNA strand (yellow). This process is mutagenic and can give rise to cancer. LA JOLLA, CA—DNA repair proteins act like the body’s editors, ...

A team of international researchers at the University of Oxford (Oxford) and Nanyang Technological University, Singapore (NTU Singapore), has discovered a new process for repairing damaged DNA that is ...

Think of your skin as your body’s shield of armor. It’s your first barrier of defense against environmental factors, but over time, it will show the remnants of hard-won battles against the elements ...