Eukaryotic genome stability relies on the presence of telomeres, specialized protein–DNA complexes that compose the very ends of the linear chromosomes 1. Telomeres form protective caps at the ends of ...

The DNA in the cell nuclei of higher organisms is tightly coiled around protein complexes called nucleosomes, which repress gene expression. Researchers in Germany have now developed a model that ...

In both physics and chemistry, the mesoscopic scale refers to the length scale on which the properties of a material or phenomenon can be studied, without entering into a discussion about the behavior ...

An imaging method that reveals a much more diverse and flexible DNA-protein chromatin chain than previously thought has now been developed by researchers. The result suggests a nimbler structure to ...

The two-stage design is a common cost-effective approach for genome-wide association studies. The first stage serves as a screening to identify a subset of single-nucleotide polymorphisms (SNPs) from ...

Scientists have created an unprecedented 3-dimensional structural model of a key molecular "machine" known as the BAF complex, which modifies DNA architecture and is frequently mutated in cancer and ...

IIIF provides researchers rich metadata and media viewing options for comparison of works across cultural heritage collections. Visit the IIIF page to learn more. This machine is an automated DNA/RNA ...

G-quadruplexes (G4s) are non-canonical nucleic acid structures formed by guanine-rich DNA sequences and stabilized by Hoogsteen hydrogen bonds and monovalent cations. These structures are biologically ...