The Nature Index 2025 Research Leaders — previously known as Annual Tables — reveal the leading institutions and countries/territories in the natural and health sciences, according to their output in ...

Abstract: Bioactuators composed of cultured skeletal muscle have unique features such as self-repair and glucose-driven, and are expected to be applied to welfare and medical devices. For the ...

- The combination of ASC47 low dose with tirzepatide in diet-induced obese (DIO) mice resulted in an 87% greater reduction in body weight compared to tirzepatide monotherapy. - ASC47 low dose in ...

Few large scale prediction models of clinical outcomes in repaired tetralogy of Fallot (rTOF) exist. Further, contraction fraction, a novel parameter indexing stroke volume by mass reflecting ...

This is a valuable study that develops a new model of the way muscle responds to perturbations, synthesizing models of how it responds to small and large perturbations, both of which are used to ...

In a serendipitous discovery, UC San Diego researchers using cryo-EM technology captured the first visualizations of the 3-D structure of the muscle acetylcholine receptor in fetal and adult muscles.

GPCRs (G-protein-coupled receptors) play a central role in the regulation of smooth muscle cell (SMC) contractility, but the function of SMC-expressed orphan GPCR class C group 5 member C (GPRC5C) is ...

The basic physiological principles of muscle contraction are well established: when muscle cells are excited, myosin heads in the sarcomere thick filaments bind to actin thin filaments and undergo a ...

Illustration of the interacting thick and thin filaments in the cardiac sarcomere based on structural cryo electron-tomography data. Credit: MPI of Molecular Physiology Scientists captured the first ...

Introduction: Skeletal muscle is responsible for multiple functions for maintaining energy homeostasis and daily activities. Muscle contraction is activated by nerve signals, causing calcium release ...

During the peer-review process the editor and reviewers write an eLife assessment that summarises the significance of the findings reported in the article (on a scale ranging from landmark to useful) ...