This whitepaper highlights a ligation-based workflow that enhances gRNA purity and yield, delivering consistent performance for demanding genome editing applications.

CRISPR-Cas systems are adaptive immune systems found in prokaryotes that defend against invading nucleic acids through CRISPR ...

Recently, demands in RNA manufacturing for long-chain RNAs exceeding 100 nucleotides, such as single guide RNA (sgRNA) for genome editing, have been increasing. Generally, these types of RNA are ...

A new tool greatly improves scientists’ ability to identify and study proteins that regulate gene activity in cells, ...

Peking University, June 27, 2025: To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian cells, researchers from Peking University ...

Chemists at University College London have shown how two of biology's most fundamental ingredients, RNA (ribonucleic acid) and amino acids, could have spontaneously joined together at the origin of ...

A novel chemo-enzymatic approach to making synthetic 100-unit oligonucleotide single guide RNA (sgRNA) increases both purity and yield, according to its developers at F. Hoffmann-La Roche and ...

In modern functional genomics, understanding how specific genes control cellular behavior requires both targeted intervention and high-resolution analysis. That’s where Perturb-Seq comes in—a method ...