EXPORT MECHANISM: The tRNA must mature inside the nucleus before export. tRNAs are aminoacylated, and only tRNAs charged with an amino acid are exported efficiently. Export occurs when the tRNA is ...

Scientists have uncovered key new information towards understanding the crucial first step in protein synthesis, the process by which the genetic code, harbored within DNA and copied into RNA, is ...

Ribosome Assembly: New research shows that neurons not only synthesize proteins locally near synapses. They can also assemble ribosomes at synapses. Dynamic Regulation: Local ribosome maturation ...

This narrated animation illustrates the process of protein synthesis, starting with chromosomal DNA inside the cell's nucleus. A gene is transcribed into messenger RNA, which leaves the nucleus and ...

We have investigated the contribution of an individual nucleus to intracellular and surface membranes in multinucleated muscle fibers. Using a retroviral vector, we introduced the gene encoding the ...

Elongation, a crucial step in the translation process of protein synthesis, gets disrupted by amino acid sequences with an abundance of N-terminal aspartic and glutamic acid residues in eukaryotic ...

Making blood in the lab can be hard because scientists don’t know what triggers a key final step in red blood cell maturation ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, No. 8 (Apr. 15, 1987), pp. 2317-2321 (5 pages) The subcellular distribution of v-sis-related protein(s) was ...

Factor-pooling by ribosomes caught on video using state-of-art high-speed atomic force microscopy technology. Ribosomes are the complexes of ribonucleoproteins at the heart of protein synthesis in ...

Disease-causing huntingtin, shown in red, interacts with ribosomes, shown in green, in a striatal neuron. The nucleus is blue. [Nicolai Urban of Max Planck Institute for Neuroscience in Jupiter, ...