BACKGROUND: Alternative splicing plays crucial roles in normal heart development and cardiac disease by influencing protein-coding sequences, functional domains, and molecular networks. However, a ...

This valuable study analyzes aging-related chromatin changes through the lens of intra-chromosomal gene correlation length, which is a novel computational metric that captures spatial correlations in ...

The world of cells is surprisingly noisy. Each cell carries unique genetic information, but when we try to measure cellular activity, signals can be lost or blurred, and differences between ...

rescueSim is an R package for simulating repeated measures (paired/longitudinal) single-cell RNA-sequencing (scRNA-seq) data. It is designed to support power analysis, benchmarking, and method ...

First, I'd like to thank you for developing Remora. It has been an invaluable tool for my direct RNA sequencing data analysis. I am currently using Remora to compare modified versus canonical RNA ...

Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous clinical picture that is closely related to extracardiac comorbidities such as obesity, hypertension, and diabetes and is ...

Estimating the cell type composition in a tissue sample using bulk data is a major challenge in cancer research. To address this, researchers at Oregon Health & Science University (OHSU) have ...

This new article publication from Acta Pharmaceutica Sinica B, discusses how single-cell RNA sequencing reveals that Shen-Bai-Jie-Du decoction retards colorectal tumorigenesis by regulating the ...

ICE is arresting more and more migrants who have not been accused of crimes. President Donald Trump campaigned for president on the promise of mass deportations that targeted criminals-- and while ICE ...